I would have to say samaus, since she has the best evasion, and has everything in one arm to defend from someone else or even attack, but others choose to differ...
Samaus:Metroid Series
Master Chief:Halo & Halo 2
Neo:The Matrix Trilogy
it sucks to be alone
if anyone looks at my signiture, yes, i know it actually looks like i think neo is better, but i really think samaus is
well if they did ever encounter each other, it would be down to master chief and samus because neo only has powers in the matrix, then judging out of samus and master....it would be samus, all she has to do is drop bombs near him and roll away....would he have full armoury? and would samus?
wow... thats a triple post... plus the spelling of smaus wrong twice... lol
but samus would win... after playing my friends on prime 2... definately... lol
but would it be in the matrix? because neo rules the matrix so he would win
Samus_Aran would come and pwn them all Matrix-style with the Yasminkov Series.
The fact that I named my strongest PSO character after Samus Aran tells you something.
Well if it's inside the matrix then Neo would win, but if it's outside the matrix then :flips a coin: It's heads. Samus would win against Master Chief, Neo would probaly hide somewhere until he sould get to a ship and use the EMP on Samus shuting down her suit thus declare himself the winner.

defently samus and you also spelled her name wrong. i mean heck she can get the mother brain on her side >

:dead: to the rest
Master Chief. Not only are his weapons kick-ass, but he has a shield.
Silly rabbits you all know putting the three of them in a battle would destroy the world with its awsome special effects and bullet time =3